Recent Evidence on the Management of
Narcolepsy: Improving Outcomes through Expert Treatment Strategies
A continuing medical education
activity provided by NAMCP and AAMCN
This activity is an archive from the live session from the 2020
Spring Managed Care Forum. If you participated in the live session,
you are not eligible for continuing education credits from this
This activity is valid from July 15, 2020 to August 1, 2021
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This activity is intended for healthcare professionals practicing in
managed care environments.
This activity is supported by
an educational grant from
Narcolepsy is a chronic disorder of hypersomnia that affects the
brain’s ability to control sleep-wake cycles. Narcolepsy patients
experience severe excessive daytime sleepiness (EDS) that leads to
involuntary somnolence during regular activities that could put the
patient and others in a harmful situation, such as driving, eating,
or talking. Narcolepsy can interfere with psychological, social, and
cognitive function and development and can inhibit academic, work,
and social activities. Greater awareness of the disorder and its
symptoms can help accurately and efficiently diagnosis the disease.
As research continues to grow, better treatments for narcolepsy are
becoming available. Sleep studies are an essential part of the
evaluation and diagnosis of patients with narcolepsy. Symptoms can
include EDS, sleep paralysis, hallucinations, but cataplexy is the
most specific symptom and occurs in almost no other diseases. The
combination of an overnight polysomnogram (PSG) followed by a
multiple sleep latency test (MSLT) can provide the proper evidence
of narcolepsy while excluding other sleep disorders.
Treatment of narcolepsy can include both nonpharmacologic and
pharmacologic components. Most patients improve if they maintain a
regular sleep schedule, which is typically around 8 hours per night.
Pharmacologic treatment of narcolepsy involves the use of stimulants
to the central nervous system such as methylphenidate, modafinil,
dextroamphetamine sulfate, methamphetamine, and amphetamine. These
medications help reduce daytime sleepiness, improving the symptoms
in around 70% of patients. There are newer treatments that are
currently undergoing clinical trials and are awaiting approval by
the FDA, such as solriamfetol, which would help to treat excessive
sleepiness in narcolepsy.
Upon completion of this
activity, participants will be able to:
Discuss current guidelines and
recent evidence of current and emerging agents in the treatment
Explore goals for optimal diagnosis
of narcolepsy, including shortening the time of diagnosis and
using clinical tools to detect persistent excessive sleepiness
Assess the clinical efficacy and
safety data for pharmacologic therapies resulting in proper
Analyze the clinical and
socioeconomic burden of narcolepsy and implement strategies to
reduce the burden
||Michael J Thorpy, MD
Professor of Neurology
Albert Einstein College of Medicine
Director, Sleep-Wake Disorders Center
Montefiore Medical Center
serves as a consultant and research investigator for
Jazz Pharmaceuticals, Flamel Technologies, Balance
Therapeutics, Suven Life Sciences, Axsome Therapeutics,
and Takeda Pharmaceuticals. His presentation has been
peer reviewed for any bias.
MD has no real or perceived financial relationships to
Jeremy Williams has no real or perceived financial
relationships to disclose.
Jacqueline Cole, RN, MS, CMCN has no real or perceived
financial relationships to disclose.
NAMCP and/or the presenter
has copyright or has received permissions for use of
materials provided in this activity.
Accreditation & Designation
This activity has been planned and implemented in accordance with
the accreditation requirements and policies of the Accreditation
Council for Continuing Medical Education (ACCME) through the joint
providership of the National Association of Managed Care Physicians
(NAMCP) and American Association of Managed Care Nurses (AAMCN). The
National Association of Managed Care Physicians is accredited by the
ACCME to provide continuing medical education for physicians.
NAMCP designates this enduring material for a maximum of 1 AMA
PRA Category 1 credit(s)TM. Each
physician should claim credit commensurate with the extent of their
participation in the activity.
The American Association of Managed Care Nurses is accredited as a
provider of nursing continuing professional development by the
American Nurses Credentialing Center's Commission on Accreditation.
Nurses who complete this activity and achieve a passing score will
receive 1 hour in nursing continuing professional development.
This activity has been approved by the American Board of Managed
Care Nursing for 1.0 contact hours toward CMCN recertification
This activity is supported by
an educational grant from
NAMCP and/or this website does not
provide medical advice, diagnosis or treatment. NAMCP does not
endorse or imply endorsement of the content on any linked website.
This website is to be used as an informational resource. With any
health related concern, consult with your physician or healthcare
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