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This activity is intended for healthcare professionals practicing in
managed care environments.
This activity is supported by
educational grants from
Merck Sharp & Dohme Corp. and ViiV Healthcare
The human immunodeficiency virus (HIV) is a lentivirus that causes
HIV infection and over time acquired immunodeficiency syndrome
(AIDS). AIDS is a condition in humans in which progressive failure
of the immune system allows life-threatening opportunistic
infections and cancers to thrive. HIV infects vital cells in the
human immune system such as helper T cells, macrophages, and
dendritic cells. HIV infection leads to low levels of CD4+ T cells
through a number of specific mechanisms. When CD4+ T cell numbers
decline below a critical level, cell-mediated immunity is lost, and
the body becomes progressively more susceptible to opportunistic
infections. The CDC estimates that 1,218,400 persons in the United
States aged 13 years and older are living with HIV infection.
Additionally, an estimated 6,955 people died from HIV and AIDS in
2018. Fortunately for patients with HIV, several new therapies have
become available over the past few years, and more are set to become
available soon. With so many new options entering the treatment
paradigm, it is critical that medical directors, practicing
physicians, nurses and other healthcare professionals are updated on
these emerging options and guidelines and strategies for
implementing them into the treatment paradigm and individualizing
therapy, which will ultimately improve clinical and economic
Treatment regimens vary and carry important differences between
therapeutic options that are clinically relevant to healthcare
professionals. HIV treatment focuses on controlling the disease and
living longer, healthier lives. Antiretroviral therapy (ART) is the
use of HIV medicines to treat HIV infection. ART has evolved
considerably over the past three decades. With many antiretroviral
drugs, combinations, and classes available, health care providers
have multiple choices regarding ART. While these choices provide
clinicians with many useful options, they also lead to challenges.
One of the biggest challenges for clinicians is individualizing the
care of HIV-positive patients and understanding when certain ART
therapies and strategies are appropriate, and when they are not.
Numerous studies have shown that ART must be tailored to the
individual patient and his or her abilities and diverse needs.
Fortunately, new treatments have become available over the past
couple of years offering physicians additional options to address
the unmet needs of these HIV patients, including combination
regimens. Additionally, more agents and combinations are undergoing
regulatory review that offer long acting benefits. Options for HIV
prevention and treatment continue to expand at a rapid pace.
Upon completion of this
activity, participants will be able to:
Examine the clinical and economic
impact of an HIV infection on a patient
Apply recent clinical trial data to
identify appropriate patient populations for new and emerging
2-drug regimens, including long-acting ART
Compare and contrast new and
emerging antiretroviral therapies (ART) based on the latest
evidence for their efficacy, safety, and adherence potential
Identify strategies to optimize
patient-centered HIV medication therapy management and adherence
Align managed care decisions with
updated guidelines and evidence on initial ART selection and ART
switching based on patient-specific factors, including
comorbidities, concomitant medications, age, adherence, and
||Anne Monroe, MD, MSPH
Department of Epidemiology and Biostatistics
Milken Institute School of Public Health
The George Washington University
has no relevant financial relationships to disclose.
MD has no real or perceived financial relationships to
Jeremy Williams has no real or perceived financial
relationships to disclose.
Jacqueline Cole, RN, MS, CMCN has no real or perceived
financial relationships to disclose.
NAMCP and/or the presenter
has copyright or has received permissions for use of
materials provided in this activity.
Accreditation & Designation
This activity has been planned and implemented in accordance with
the accreditation requirements and policies of the Accreditation
Council for Continuing Medical Education (ACCME) through the joint
providership of the National Association of Managed Care Physicians
(NAMCP) and American Association of Managed Care Nurses (AAMCN). The
National Association of Managed Care Physicians is accredited by the
ACCME to provide continuing medical education for physicians.
NAMCP designates this enduring material for a maximum of 1 AMA
PRA Category 1 credit(s)TM. Each
physician should claim credit commensurate with the extent of their
participation in the activity.
The American Association of Managed Care Nurses is accredited as a
provider of nursing continuing professional development by the
American Nurses Credentialing Center's Commission on Accreditation.
Nurses who complete this activity and achieve a passing score will
receive 1 hour in nursing continuing professional development.
This activity has been approved by the American Board of Managed
Care Nursing for 1.0 contact hours toward CMCN recertification
This activity is supported by educational grants from
Merck Sharp & Dohme Corp. and ViiV Healthcare
NAMCP and/or this website does not
provide medical advice, diagnosis or treatment. NAMCP does not
endorse or imply endorsement of the content on any linked website.
This website is to be used as an informational resource. With any
health related concern, consult with your physician or healthcare
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