Navigating an Increasingly Complex Treatment Landscape in the Management of Acute Myeloid Leukemia (AML): Improving Clinical and Economic Outcomes

A continuing medical education activity sponsored by NAMCP and AAMCN.

This activity is an archive from the live session from the 2020 Spring Managed Care Forum. If you participated in the live session, you are not eligible for continuing education credits from this archive

This activity is valid from July 15, 2020 to August 1, 2021

Instructions for CME/CNE: Complete the pre-test, listen to the audio and view the slides, complete the post test, complete the evaluation form and hit submit. You will be asked to enter your name and email address on the pre-test, evaluation and post-test. If you close your internet browser without completing the post test, you will have ONE more opportunity to complete. A score of 70% must be achieved on the post test to receive continuing education credits. If you do not pass the post test after two attempts, you will not be eligible to try again. Once you complete the evaluation form and score 70% or higher on your post test, you will automatically be given your certificate.

To print or save your certificate, you will need to click on the “download” button and either print or save.

 

Audience: This activity is intended for healthcare professionals practicing in managed care environments.

This presentation is supported by educational grants from
AbbVie and Jazz Pharmaceuticals

Description:
Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal white blood cells that build up in the bone marrow and interfere with the production of normal blood cells. AML is the most common acute leukemia affecting adults, and its incidence increases with age. Although AML is a relatively rare disease, accounting for roughly 1.2% of cancer deaths in the United States, its incidence is expected to increase as the population ages. The American Cancer Society estimates that there will be approximately 21,380 new cases of AML and 10,590 deaths from AML in the United States in 2020. The five-year survival rate has not improved in older patients despite of 40 years of research. Fortunately for patients with AML, many new treatments have recently been approved for use. These options, which are among the first new treatments in AML since 1990, have begun to drastically change the treatment paradigm. With that change comes a knowledge gap among physician medical directors, oncologists, practicing physicians and nurses. For this reason, it is critical that these HCPs are educated and updated on these emerging options and strategies for their implementation into the treatment paradigm, which will ultimately improve patient outcomes in the AML patient population.

AML has several subtypes and treatment and prognosis vary among subtypes. After AML has been diagnosed, tests are done to find out the subtype. This is especially important, as several new treatments focus on AML disease with certain mutations or on patients who are unable to receive chemotherapy regimens. Following older treatment paradigms, AML has been cured in 35-40% of people under 60 years old, but only in 5-15% of people over 60 years old. Fortunately for people with AML, that treatment paradigm is set to change drastically, as novel targeted agents have shown improved efficacy and safety outcomes in clinical trial research.

Upon completion of this activity, participants will be able to:

  • Describe the clinical and economic burden of AML in terms of relative survival, mortality, drug utilization, adverse event management, and hospitalizations

  • Compare and contrast the efficacy, safety and mechanisms of action of novel therapeutics in AML, including newer targeted, cytotoxic, and antibody-based strategies, in a range of patient populations

  • Examine the evolving role of newer cytotoxic therapy options and distinguish differences in new chemotherapy induction regimens compared to standard formulations

  • Analyze novel treatment approaches in the context of evolving treatment paradigms in the management of AML including methods to personalize care for elderly patients or those with poor performance status

  • Discuss the adverse effect of cost-sharing and exclusive formulary strategies on patient access and therapeutic persistence in AML

  • Employ interventions such as clinical pathways and site of care initiatives for optimal cost management and improved outcomes in AML
     

Faculty: Jeffrey E. Lancet, MD
Chair, Department of Malignant Hematology
Moffitt Cancer Center
Professor, Department of Oncologic Sciences
University of South Florida

Disclosure:

Dr. Lancet serves on an advisory board for Agios Pharmaceuticals and Astellas. He serves as a consultant to Agios Pharmaceuticals, Astellas, AbbVie Inc., Daiichi Sankyo, Inc., and Jazz Pharma. His presentation has been peer reviewed for any bias.
  Planning Committee:
Bill Williams, MD has no relevant financial relationships to disclose.
Jeremy Williams has no relevant financial relationships to disclose.
Will Williams has no relevant financial relationships to disclose.
Jacqueline Cole, RN, MS, CMCN has no relevant financial relationships to disclose.

NAMCP and/or the presenter has copyright or has received permissions for use of materials provided in this activity.

Accreditation & Designation
This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the National Association of Managed Care Physicians (NAMCP) and American Association of Managed Care Nurses (AAMCN). The National Association of Managed Care Physicians is accredited by the ACCME to provide continuing medical education for physicians.

NAMCP designates this enduring material for a maximum of 1 AMA PRA Category 1 credit(s)TM. Each
physician should claim credit commensurate with the extent of their participation in the activity.

The American Association of Managed Care Nurses is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center's Commission on Accreditation.

Nurses who complete this activity and achieve a passing score will receive 1 hour in continuing
nursing credit.

This activity has been approved by the American Board of Managed Care Nursing for 1.0 contact hours toward CMCN recertification requirements.

This presentation is supported by educational grants from
AbbVie and Jazz Pharmaceuticals

NAMCP and/or this website does not provide medical advice, diagnosis or treatment. NAMCP does not endorse or imply endorsement of the content on any linked website. This website is to be used as an informational resource. With any health related concern, consult with your physician or healthcare professional.

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