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This activity is intended for healthcare professionals practicing in
managed care environments.
This activity is supported by
an educational grant from
Rheumatoid arthritis (RA) is a long-lasting autoimmune disorder that
occurs when the immune system mistakenly attacks the body's own
tissues. It typically results in warm, swollen, and painful joints,
and pain and stiffness often worsen following rest. Most commonly,
the wrist and hands are involved, with the same joints typically
involved on both sides of the body. The disease may also affect
other parts of the body, which results in a low red blood cell
count, inflammation around the lungs, and inflammation around the
heart. Fortunately for patients with RA, several new medications
have become available recently. Diagnosis is done through
examination, including x-rays and ultrasounds, and blood testing for
certain indications and to rule out other possible causes for the
symptoms. There is no cure for RA, treatment is to control the pain,
during flair ups especially, and to prevent joint damage.
Treatment regimens vary and carry important differences between
therapeutic options that are clinically relevant to healthcare
professionals. An understanding of the pathogenesis of RA and the
role of different treatment approaches, including current and
emerging therapies, will assist healthcare providers in determining
the best course of therapeutic management for optimal long-term
patient outcomes. RA treatment focuses on controlling the disease
and its symptoms. However, with all of the currently available
non-biologic and biologic therapies, only about 1/3 of patients
treated for RA ever achieve clinical remission. Fortunately, new and
emerging treatment strategies have offered additional therapeutic
options to address the unmet needs of these patients. Clinicians
have recently been equipped with more treatment options, including
new biologic DMARDs, which have demonstrated an improved efficacy
Upon completion of this
activity, participants will be able to:
Assess the role of anti-citrullinated
protein antibodies (ACPAs), among other RA biomarkers, as part
of the pathophysiology of RA
Explore efficacy and safety profiles
of current and emerging biologic therapies for the treatment of
moderate-to-severe RA for achieving individualized treatment
Critically evaluate data regarding
the utility of RA biomarkers, such as ACPAs, and their assays in
the early diagnosis of RA and its personalized management
Assess the managed care
considerations of biomarkers in the management of RA and the
effect they have on the current moderate-to-severe RA management
Evaluate current evidence-based
guidelines and their emphasis on early diagnosis and aggressive
treatment for patients with RA
Explore available decision support
tools with health plan affiliated rheumatology professionals to
improve outcomes for patients with RA
||Jeffrey Curtis, MD, MS,
Marguerite Jones Harbert
Gene Ball Endowed Professor of Medicine
UAB Division of Clinical Immunology & Rheumatology
serves as a consultant and has received research/grant
support from Amgen, Abbvie, BMS, Corrona, Lilly, Merck,
Myriad, Novartis, Pfizer, Roche, Sanofi/Regeneron,
Sandoz, Scipher, and Samsung
MD has no real or perceived financial relationships to
Jeremy Williams has no real or perceived financial
relationships to disclose.
Jacqueline Cole, RN, MS, CMCN has no real or perceived
financial relationships to disclose.
NAMCP and/or the presenter
has copyright or has received permissions for use of
materials provided in this activity.
Accreditation & Designation
This activity has been planned and implemented in accordance with
the accreditation requirements and policies of the Accreditation
Council for Continuing Medical Education (ACCME) through the joint
providership of the National Association of Managed Care Physicians
(NAMCP) and American Association of Managed Care Nurses (AAMCN). The
National Association of Managed Care Physicians is accredited by the
ACCME to provide continuing medical education for physicians.
NAMCP designates this enduring material for a maximum of 1 AMA
PRA Category 1 credit(s)TM. Each
physician should claim credit commensurate with the extent of their
participation in the activity.
The American Association of Managed Care Nurses is accredited as a
provider of nursing continuing professional development by the
American Nurses Credentialing Center's Commission on Accreditation.
Nurses who complete this activity and achieve a passing score will
receive 1 hour in nursing continuing professional development.
This activity has been approved by the American Board of Managed
Care Nursing for 1.0 contact hours toward CMCN recertification
This activity is supported by an educational grant from
NAMCP and/or this website does not
provide medical advice, diagnosis or treatment. NAMCP does not
endorse or imply endorsement of the content on any linked website.
This website is to be used as an informational resource. With any
health related concern, consult with your physician or healthcare
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