Best Practices in the Prevention and Management of HIV: Optimizing PrEP and ART Managed Care Decision Making for Improved Clinical and Economic Outcomes

Audience: This activity is intended for healthcare professionals practicing in managed care environments.

This activity is supported by educational grants from
Gilead Sciences and ViiV Healthcare

Description:
The human immunodeficiency virus (HIV) is a lentivirus that causes HIV infection and over time acquired immunodeficiency syndrome (AIDS). AIDS is a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. HIV infects vital cells in the immune system such as helper T cells, macrophages, and dendritic cells. HIV infection leads to low levels of CD4+ T cells through a number of specific mechanisms. When CD4+ T cell numbers decline below a critical level, cell-mediated immunity is lost, and the body becomes progressively more susceptible to opportunistic infections. The CDC estimates that 1,218,400 persons in the United States aged 13 years and older are living with HIV infection. Additionally, an estimated 15,815 people died from HIV and AIDS in 2022. Fortunately for patients with HIV, several new therapies have become available over the past year, including long-acting injectable therapies for both treatment and PrEP and options for heavily treatment-experienced (HTE) patients. With so many new options entering the treatment paradigm, it is critical that medical directors, practicing physicians, nurses, and other healthcare professionals are updated on these emerging options and guidelines and strategies for implementing them into the treatment paradigm and individualizing therapy, which will ultimately improve clinical and economic outcomes.

Upon completion of this activity, participants will be able to:

• Identify the populations who are at risk for HIV, and the factors that contribute to the underutilization of preexposure prophylaxis (PrEP) in eligible patient populations
• Explore optimal PrEP and ART regimens based on patient- or drug-related factors, including age, comorbidities, concomitant medications, potential for ART-related toxicities, adherence, or patient preferences
• Analyze the role of long-acting injectable therapy in HIV management and review which patients would benefit from long-acting ART or PrEP
• Assess the current antiretroviral therapy (ART) landscape and the unmet needs that hinder the achievement of viral suppression in diverse patient populations
• Identify effective primary prevention strategies for CV disease specifically tailored for people with HIV
• Evaluate the disparities in HIV PrEP related to race, gender, age, and other social determinants of health

Faculty:
David A. Wohl, MD
Professor, Institute of Global Health and Infectious Diseases
The University of North Carolina at Chapel Hill
Site Leader, UNC HIV Clinical Research Unit at Chapel Hill
david_wohl@med.unc.edu

Disclosure Information:
As accredited providers, NAMCP and AAMCN must ensure balance, independence, objectivity, and scientific rigor in all of their activities. All faculty participating in this activity are required to disclose to NAMCP/AAMCN any financial relationships with ineligible companies. NAMCP/AAMCN in turn discloses all relevant financial conflicts to the learners. NAMCP/AAMCN disclosure policy adheres to The Standards for Integrity and Independence in Accredited Continuing Education. All relevant conflicts of interest have been mitigated prior to the commencement of the activity. See below for conflicts of interest.

Disclosures (Relevant Financial Relationships with Ineligible Companies in the Last 24 Months):
Dr. Wohl has served as a consultant for Gilead Sciences, Merck, Regeneron, and Theratechnology. He has received grant/research support from Merck. All relevant financial relationships have been mitigated.

Planning Committee Disclosures (Relevant Financial Relationships with Ineligible Companies in the Last 24 Months):
Bill Williams, MD has no relevant financial relationship with an ineligible company to disclose.
Jeremy Williams has no relevant financial relationship with an ineligible company to disclose.
Jacqueline Cole, RN, MS, CMCN has no relevant financial relationship with an ineligible company to disclose.

NAMCP and/or the presenter has copyright or has received permissions for use of materials provided in this activity.

Accreditation & Designation
This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the National Association of Managed Care Physicians (NAMCP) and American Association of Managed Care Nurses (AAMCN). The National Association of Managed Care Physicians is accredited by the ACCME to provide continuing medical education for physicians.

NAMCP designates this enduring material for a maximum of 1 AMA PRA Category 1 credit(s)^TM. Each physician should claim credit commensurate with the extent of their participation in the activity.

The American Association of Managed Care Nurses is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center's Commission on Accreditation.

Nurses who complete this activity and achieve a passing score will receive 1 hour in nursing continuing professional development.

This activity has been approved by the American Board of Managed Care Nursing for 1.0 contact hours toward CMCN recertification requirements.

NAMCP and/or this website do not provide medical advice, diagnosis, or treatment. NAMCP does not endorse or imply endorsement of the content on any linked website. This website is to be used as an informational resource. With any health-related concern, consult with your physician or healthcare professional.

This activity is supported by educational grants from
Gilead Sciences and ViiV Healthcare

NAMCP and/or this website does not provide medical advice, diagnosis or treatment. NAMCP does not endorse or imply endorsement of the content on any linked website. This website is to be used as an informational resource. With any health related concern, consult with your physician or healthcare professional.