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This activity is intended for healthcare professionals practicing in
managed care environments.
This activity is supported by
educational grants from
Merck Sharp & Dohme Corp. and ViiV Healthcare
The human immunodeficiency virus (HIV) is a lentivirus that causes
HIV infection and over time acquired immunodeficiency syndrome
(AIDS). AIDS is a condition in humans in which progressive failure
of the immune system allows life-threatening opportunistic
infections and cancers to thrive. HIV infects vital cells in the
human immune system such as helper T cells, macrophages, and
dendritic cells. HIV infection leads to low levels of CD4+ T cells
through a number of specific mechanisms. When CD4+ T cell numbers
decline below a critical level, cell-mediated immunity is lost, and
the body becomes progressively more susceptible to opportunistic
infections. The CDC estimates that 1,218,400 persons in the United
States aged 13 years and older are living with HIV infection.
Additionally, an estimated 6,955 people died from HIV and AIDS in
2018. Fortunately for patients with HIV, several new therapies have
become available over the past few years, and more are set to become
Treatment regimens vary and carry important differences between
therapeutic options that are clinically relevant to healthcare
professionals. HIV treatment focuses on controlling the disease and
living longer, healthier lives. Antiretroviral therapy (ART) is the
use of HIV medicines to treat HIV infection. ART has evolved
considerably over the past three decades. With many antiretroviral
drugs, combinations, and classes available, health care providers
have multiple choices regarding ART. While these choices provide
clinicians with many useful options, they also lead to challenges.
One of the biggest challenges for clinicians is individualizing the
care of HIV-positive patients and understanding when certain ART
therapies and strategies are appropriate, and when they are not.
Numerous studies have shown that ART must be tailored to the
individual patient and his or her abilities and diverse needs.
Fortunately, new treatments have become available over the past
couple of years offering physicians additional options to address
the unmet needs of these HIV patients, including combination
regimens. Additionally, more agents and combinations are now
available for heavily pretreated patients. Options for HIV
prevention and treatment continue to expand at a rapid pace. To
improve outcomes for patients, clinicians working in healthcare
settings must keep current with the latest treatments, guideline
recommendations, strategies for individualizing therapy, and best
practices for coordinating care and specialty referral.
Upon completion of this
activity, participants will be able to:
Discuss the clinical and economic
burden of HIV, including factors that contribute to poor
prognosis and increased costs
Explore recent clinical trial data
to identify appropriate patient populations for new and emerging
2-drug regimens, including long-acting ART
Examine the role of newer therapies
for heavily treatment-experienced (HTE) adults with
multidrug-resistant HIV-1 infection
Evaluate optimal ART regimens based
on patient- or drug-related factors, including age,
comorbidities, concomitant medications, potential for
ART-related toxicities, adherence, or patient preferences
Identify strategies to optimize
patient-centered HIV medication therapy management and adherence
Assess the managed care
considerations of new and emerging therapies, including
combination options and long-acting ART, by exploring where
these agents fit in the HIV management paradigm
||Gary Owens, MD
Gary Owens Associates
serves on as a consultant for Lilly, ICON, Magnolia
Innovation, MCRA, Octave Biosciences, Vertex and Xcenda.
His presentation has been peer reviewed for any bias.
His presentation has been reviewed for any bias.
MD has no financial relationships with ineligible
companies to disclose.
Jeremy Williams has no financial relationships with
ineligible companies to disclose.
Jacqueline Cole, RN, MS, CMCN has no financial
relationships with ineligible companies to disclose.
NAMCP and/or the presenter
has copyright or has received permissions for use of
materials provided in this activity.
Accreditation & Designation
This activity has been planned and implemented in accordance with
the accreditation requirements and policies of the Accreditation
Council for Continuing Medical Education (ACCME) through the joint
providership of the National Association of Managed Care Physicians
(NAMCP) and American Association of Managed Care Nurses (AAMCN). The
National Association of Managed Care Physicians is accredited by the
ACCME to provide continuing medical education for physicians.
NAMCP designates this enduring material for a maximum of 1 AMA
PRA Category 1 credit(s)TM. Each
physician should claim credit commensurate with the extent of their
participation in the activity.
The American Association of Managed Care Nurses is accredited as a
provider of nursing continuing professional development by the
American Nurses Credentialing Center's Commission on Accreditation.
Nurses who complete this activity and achieve a passing score will
receive 1 hour in nursing continuing professional development.
This activity has been approved by the American Board of Managed
Care Nursing for 1.0 contact hours toward CMCN recertification
This activity is supported by educational grants from
Merck Sharp & Dohme Corp. and ViiV Healthcare
NAMCP and/or this website does not
provide medical advice, diagnosis or treatment. NAMCP does not
endorse or imply endorsement of the content on any linked website.
This website is to be used as an informational resource. With any
health related concern, consult with your physician or healthcare
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