Treating Chronic Inflammatory
Demyelinating Polyneuropathy With Immunoglobulin: Managed Care
Considerations in an Evolving Treatment Paradigm
A continuing medical education
activity provided by NAMCP and AAMCN
This activity is an archive from the live session from the 2020 Fall
Managed Care Forum. If you participated in the live session, you are
not eligible for continuing education credits from this archive.
This activity is valid from January 1, 2021 to March 1, 2022
Instructions for CME/NCPD: Complete the pre-test, listen to the
audio and view the slides, complete the post test, complete the
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This activity is intended for healthcare professionals practicing in
managed care environments.
This activity is supported by
an educational grant from
Chronic inflammatory demyelinating polyneuropathy (CIDP) is an
acquired immune-mediated inflammatory disorder of the peripheral
nervous system. In CIDP, the myelin sheath, the protective covering
of the nerves, is damaged. This may result in numbness or tingling,
muscle weakness, fatigue, and other symptoms. CIDP effects can
worsen over time, leading to significant activity limitations and a
decreased quality of life. CIDP can occur at any age and is more
common in men than in women. Approximately 30 percent of CIDP
patients will progress to wheelchair dependence if not treated.
Fortunately for these patients, novel immunoglobulin replacement
therapies have recently become available that have shown improved
efficacy and safety as a maintenance therapy in CIDP.
First-line treatment for CIDP is currently intravenous
immunoglobulin (IVIG) and other treatments include corticosteroids
(e.g. prednisone), and plasmapheresis (plasma exchange) which may be
prescribed alone or in combination with an immunosuppressant drug.
However, recent controlled studies show how subcutaneous
immunoglobin (SCIG), which has only recently become available for
patients with CIDP, appears to be as effective for CIDP treatment as
IVIG in most patients, and with fewer systemic side effects.
Effective and timely treatment of CIDP can greatly improve the
quality of life and outcomes in CIDP patients.
Upon completion of this
activity, participants will be able to:
Examine the pathophysiology and
clinical features of chronic inflammatory demyelinating
Discuss the unmet needs and total
cost of care for CIDP, including direct costs associated with
drug therapy and associated infections from non-treatment, as
well as indirect costs
Analyze the safety and efficacy of
currently available and emerging immunoglobulin (Ig) replacement
therapies for the management of CIDP and apply them to patient
cases using evidence-based medicine
Employ shared decision-making when
choosing treatment for patients with CIDP in the initial
management and maintenance settings
Explore novel administration methods
for immunoglobulin (Ig) replacement therapies and how they are
changing the treatment paradigm
Assess methods to enable optimal
cost management of Ig replacement therapies to be realized by
multiple CIDP stakeholders including managed care organizations
||Peter D. Donofrio, MD
Professor of Neurology
Chief of the Neuromuscular Division
Vice Chairman of Compliance and Professionalism
Vanderbilt University Medical Center
Donofrio serves as a consultant for Argenx. His
presentation has been peer reviewed for any bias.
MD has no real or perceived financial relationships to
Jeremy Williams has no real or perceived financial
relationships to disclose.
Jacqueline Cole, RN, MS, CMCN has no real or perceived
financial relationships to disclose.
NAMCP and/or the presenter
has copyright or has received permissions for use of
materials provided in this activity.
Accreditation & Designation
This activity has been planned and implemented in accordance with
the accreditation requirements and policies of the Accreditation
Council for Continuing Medical Education (ACCME) through the joint
providership of the National Association of Managed Care Physicians
(NAMCP) and American Association of Managed Care Nurses (AAMCN). The
National Association of Managed Care Physicians is accredited by the
ACCME to provide continuing medical education for physicians.
NAMCP designates this enduring material for a maximum of 1 AMA
PRA Category 1 credit(s)TM. Each
physician should claim credit commensurate with the extent of their
participation in the activity.
The American Association of Managed Care Nurses is accredited as a
provider of nursing continuing professional development by the
American Nurses Credentialing Center's Commission on Accreditation.
Nurses who complete this activity and achieve a passing score will
receive 1 hour in nursing continuing professional development.
This activity has been approved by the American Board of Managed
Care Nursing for 1.0 contact hours toward CMCN recertification
This activity is supported by an educational grant from
NAMCP and/or this website does not
provide medical advice, diagnosis or treatment. NAMCP does not
endorse or imply endorsement of the content on any linked website.
This website is to be used as an informational resource. With any
health related concern, consult with your physician or healthcare
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