Strategies for Improving Patient Outcomes through Optimal Treatment and Management of Major Depressive Disorder

A continuing medical education activity sponsored by NAMCP and AAMCN.

This activity is an archive from the live session from the 2019 Fall Managed Care Forum. If you participated in the live session, you are not eligible for continuing education credits from this archive.

This activity is valid from January 1, 2020 to January 1, 2021

Instructions for CME/CNE: Complete the pre-test, listen to the audio and view the slides, complete the post test, complete the evaluation form and hit submit. You will be asked to enter your name and email address on the pre-test, evaluation and post-test. If you close your internet browser without completing the post test, you will have ONE more opportunity to complete. A score of 70% must be achieved on the post test to receive continuing education credits. If you do not pass the post test after two attempts, you will not be eligible to try again. Once you complete the evaluation form and score 70% or higher on your post test, you will automatically be given your certificate.

To print or save your certificate, you will need to click on the “download” button and either print or save.


Audience: This activity is intended for healthcare professionals practicing in managed care environments.

This presentation is supported by an educational grant from
Takeda Pharmaceuticals USA, Inc. and Lundbeck

Major depression is a debilitating condition that nearly 350 million people worldwide will experience at some point in their life. With appropriate treatment, only 70-80% of individuals with major depressive disorder (MDD) achieve a significant reduction in symptoms while as many as 50% of patients do not respond to initial treatment. In addition, more than 80% of patients with depression have a medical comorbidity or complication that often derive from alcohol or substance abuse, type 2 diabetes, isolation, work and personal conflicts, and an increased chance of suicide.

According to the Diagnostic and Statistical Manual of Mental Disorders (DSM) of the American Psychiatric Association (APA), a diagnosis of clinical depression requires the presence of depressed mood, a loss of pleasure and interest, decreased energy, changes in sleep patterns, and feelings of worthlessness, hopelessness, or guilt for a period of at least 2 weeks. Symptoms leave the patient with significant distress and impair their ability to function. Measurement-based assessment tools have helped to quantify the degree of depression; however, these tools continue to be underutilized in everyday practice. It is important to assess the overall severity of depressive symptoms as symptom severity correlates with suicide risk. Several treatment methods for MDD include psychotherapy, antidepressant medications, electroconvulsive treatment (ECT), and somatic therapies. Antidepressant treatments include selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, atypical and tricyclic antidepressants, monoamine oxidase inhibitors, and other medications. Combination therapies, including multiple pharmacological actions can affect multiple monoamine targets which can produce greater efficacy. While there are many options, the need to personalize a treatment plan for each individual patient is important to move patients suffering from MDD to remission, then recovery, and to avoid a relapse.

Upon completion of this activity, participants will be able to:

  • Evaluate the clinical data surrounding the safety and efficacy for current and emerging pharmacologic agents for patients with major depressive disorder (MDD), including their mechanism of action

  • Assess measurement-based tools for monitoring and diagnosing patients with MDD

  • Review personalized therapeutic strategies that include newer antidepressants to manage MDD symptoms while reducing adverse effects

  • Examine the differences of single vs combination therapies in patients with depression

  • Discuss the practical team-based and shared decision-making approaches to improve coordination of care

Faculty: Alan F. Schatzberg, MD
Professor, Department of Psychiatry and Behavioral Sciences
Director, Stanford Mood Disorders Center
Stanford University School of Medicine


Dr. Schatzberg has served as a consultant for Alkermes, Avanir, Bracket, Delpor, Epiodyne, Janssen, Jazz, Lundbeck, McKinsey, Merck, MSI, Myriad Genetics, Owl, Neuronetics, Pfizer, Sage, Sunovion, Takeda, and Xhale. He has received grant/research support from Janssen. He owns stock in Corcept (co-founder), Dermira, Delpor, Epiodyne, Incyte Genetics, Madrigal, Merck, Owl, Seattle Genetics, Titan, and Xhale. His presentation has been reviewed for any bias.
  Planning Committee:
Bill Williams, MD has no relevant financial relationships to disclose.
Jeremy Williams has no relevant financial relationships to disclose.
Will Williams has no relevant financial relationships to disclose.
Jacqueline Cole, RN, MS, CMCN has no relevant financial relationships to disclose.

NAMCP and/or the presenter has copyright or has received permissions for use of materials provided in this activity.

Accreditation & Designation
The National Association of Managed Care Physicians (NAMCP) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

NAMCP designates this enduring material for a maximum of 1 AMA PRA Category 1 creditsTM.

The American Association of Managed Care Nurses (AAMCN) is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center’s Commission on Accreditation.

Nurses who complete this activity and achieve a passing score will receive 1 hour in continuing
nursing credit.

This activity has been approved by the American Board of Managed Care Nursing for 1.0 contact hour toward CMCN recertification requirements.

This presentation is supported by an educational grant from
Takeda Pharmaceuticals USA, Inc. and Lundbeck

NAMCP and/or this website does not provide medical advice, diagnosis or treatment. NAMCP does not endorse or imply endorsement of the content on any linked website. This website is to be used as an informational resource. With any health related concern, consult with your physician or healthcare professional.

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