Best Approaches for Diagnosing, Treating, and Managing Patients with Major Depressive Disorder

A continuing medical education activity sponsored by NAMCP and AAMCN.

This activity is an archive from the live session from the 2019 Spring Managed Care Forum. If you participated in the live session, you are not eligible for continuing education credits from this archive.

This activity is valid from July 1, 2019 to August 1, 2020

Instructions for CME/CNE: Complete the pre-test, listen to the audio and view the slides, complete the post test, complete the evaluation form and hit submit. You will be asked to enter your name and email address on the pre-test, evaluation and post-test. If you close your internet browser without completing the post test, you will have ONE more opportunity to complete. A score of 70% must be achieved on the post test to receive continuing education credits. If you do not pass the post test after two attempts, you will not be eligible to try again. Once you complete the evaluation form and score 70% or higher on your post test, you will automatically be given your certificate.

To print or save your certificate, you will need to click on the “download” button and either print or save.


Audience: This activity is intended for healthcare professionals practicing in managed care environments.

This presentation is supported by an educational grant from
Takeda Pharmaceuticals USA, Inc. and Lundbeck

Major depression is a debilitating condition that nearly 20% of the general population in the United States will experience at some point in their life. More than 350 million people worldwide suffer from depression. With appropriate treatment, 70-80% of individuals with major depressive disorder can achieve a significant reduction in symptoms, although as many as 50% of patients may not respond to the initial treatment trial. These numbers are staggering, and many of these patients report cognitive difficulties. More than 80% of patients with depression have a medical comorbidity. Comorbidities or complications that can come from MDD include alcohol or substance abuse, type 2 diabetes, isolation, work and personal conflicts, and an increased chance of suicide.

Treatment is based on severity of depression and episode types, and may be multi-faceted, combining medication with psychotherapy. There are several treatment methods for major depression disorder, including psychotherapy, antidepressant medications, and other somatic therapies. Antidepressant treatments include selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, atypical and tricyclic antidepressants, monoamine oxidase inhibitors and other medications. Combination therapies, including multiple pharmacological actions, can affect multiple monoamine targets which can produce greater efficacy. While there are many options out there, the need to personalize a treatment plan for each individual patient is important as the ultimate goal of care providers is to move patients suffering from MDD to remission, then recovery, and to avoid a relapse.

Upon completion of this activity, participants will be able to:

  • Assess up-to-date strategies for improving assessment tools for a more accurate diagnosis in major depressive disorder (MDD)

  • Evaluate the efficacy and safety for available pharmacologic treatment modalities for patients with (MDD)

  • Review the evidence regarding single vs. combination treatment modalities

  • Discuss the challenges of achieving remission in patients with MDD, including adherence, risk of adverse effects, treatment monitoring, and utilizing a multidisciplinary care team

  • Examine the clinical data on available therapies for patients who do not respond to first-line therapies

Faculty: Charles L. Raison, MD
Mary Sue and Mike Shannon Chair for Health Minds, Children & Families and Professor
School of Human Ecology
Department of Psychiatry
School of Medicine and Public Health
University of Wisconsin-Madison


Dr. Raison serves on an advisory board for Alkermes and Shire. He serves as a consultant for Emory Healthcare and Usona Institute. His presentation has been peer reviewed for any bias.
  Planning Committee:
Bill Williams, MD has no relevant financial relationships to disclose.
Jeremy Williams has no relevant financial relationships to disclose.
Will Williams has no relevant financial relationships to disclose.
Jacqueline Cole, RN, MS, CMCN has no relevant financial relationships to disclose.

NAMCP and/or the presenter has copyright or has received permissions for use of materials provided in this activity.

Accreditation & Designation
The National Association of Managed Care Physicians (NAMCP) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

NAMCP designates this enduring material for a maximum of 1 AMA PRA Category I creditsTM.

The American Association of Managed Care Nurses (AAMCN) is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation (ANCC).

Nurses who complete this activity and achieve a passing score will receive 1 hour in continuing
nursing credit.

This activity has been approved by the American Board of Managed Care Nursing for 1.0 contact hour toward CMCN recertification requirements.

This presentation is supported by an educational grant from
Takeda Pharmaceuticals USA, Inc. and Lundbeck

NAMCP and/or this website does not provide medical advice, diagnosis or treatment. NAMCP does not endorse or imply endorsement of the content on any linked website. This website is to be used as an informational resource. With any health related concern, consult with your physician or healthcare professional.

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